Obesity is a growing public health problem worldwide with more than one billion overweight and 300 million obese people Obesity contributes to serious diseases such as diabetes and cardiovascular disease. Several reports have shown that people who spend a large part of the day sitting are at increased risk of obesity and diabetes. Our results suggest that increased leg loading, which occurs when standing up, can lead to an increased activation of a 'body's own wave' in the weight-bearing long tubular bones is more activated, and that this in turn leads to more activity in an obesity-inhibiting system and hence reduced weight. There is already a well-known system that tries to keep fat mass constant. The anti-obesity hormone hormone leptin is released into the blood from adipose tissue in relation to the size of the fat mass. Leptin exerts a negative feedback feedback in the brain, leading to reduced appetite and obesity. Unfortunately, for unknown reasons, most obese people are insensitive to leptin's anti-obesity effect. We have now shown in the prestigious American Academy of Sciences journal PNAS that the insertion of weights into the abdominal cavity or under the skin of obese mice leads to a reduction in their food intake, body weight and fat mass decrease independently of leptin. This effect seems to involve a specific cell type in the long tubular bones. We now want to study the exact mechanism of how the 'body wave' in the legs affects fat mass and appetite, probably via an effect on the brain. We also want to investigate the role of this novel system in human fat regulation.