Infectious diseases kill millions of people every year. This project maps how bacteria that cause meningitis, sepsis and cancer interact with host cells. By understanding critical steps in the disease process, we aim to develop new ways to treat, cure and prevent these diseases. The growing prevalence of antibiotic resistance makes it increasingly urgent and pressing to find new medicines for bacterial infections. The bacterium Helicobacter can cause gastritis, ulcers and eventually cancer. We have found a substance that specifically attacks the disease-causing functions of the bacterium. We want to develop this compound to go into clinical trials and test this as a new treatment method and a future alternative to antibiotics. Other serious bacterial diseases include blood poisoning and meningitis, which are dreaded medical emergencies. Still, mortality rates are as high as 15-50% according to various studies, which is due to the fact that the infection caused general activation of the inflammatory and coagulation systems. By mapping the infection, we have found new receptors and signaling pathways used by the bacteria. At the same time, the immune system needs to be characterized, as mortality is often due to the bacteria overstimulating our immune system. An important part of the project is to find new ways to influence these systems so that the disease process can be stopped.