Severe food allergy (MA) is more common than severe asthma. Many people with SEA have a great fear of accidentally ingesting what they cannot tolerate and it is an invisible disability. Life-threatening allergic reactions, anaphylaxis, are mainly caused by soil/tree nuts but there is no cure. Oral immunotherapy (OIT), where the food is eaten in increasing amounts until a maintenance dose is reached, has been tried. Allergic reactions to OIT are a problem. Anti-allergy antibody (anti-IgE) is a drug that binds allergy antibodies and prevents the allergic reaction. Stimulation of basophilic cells with allergen in test tubes (CD-sens) reflects the individual's allergen sensitivity. Three pilot patients have undergone treatment with anti-IgE and OIT, followed by CD-sens, with good results. Question: Can we improve quality of life and can tolerance be developed in adolescents with severe AD? Method: The study is independent of pharmaceutical companies. 20 adolescents with severe peanut allergy are treated with anti-IgE and start OIT with peanut (escalation from 1-10 g/day) during continued anti-IgE treatment, when CD-sens to peanut is 0. Anti-IgE treatment is tapered when the participant has eaten 10 g peanut/day for 2 months. Benefit: A curative treatment without severe side effects for those with severe AD would be of great benefit. The individual with MA can avoid the fear of life-threatening allergic reactions and unplanned hospital visits with possible hospitalization. There are major health economic benefits to be gained.