Coronary heart disease (CHD) caused by atherosclerosis is the most common cause of death in the western world, including Sweden and the rest of the Nordic countries. It has been reported that CHD incidence increases several times during the cold season and the highest incidence of CHD occurs in winter. Our aim is to understand the basic mechanisms of cold-induced lipolysis in CHD development that is related to atherosclerosis. Through this research, we hope to develop new approaches to the treatment and prevention of cardiovascular diseases. We plan to use animal models of different vascular diseases under different conditions to study the role of temperature changes on plaque development in atherosclerosis, including introducing/removing some specific genes in animal models. We will use drugs according to different principles, either alone or in combination to treat atherosclerosis-related heart disease, and collaborate with clinical cardiologists and experts to perform clinical studies. Although the activation of brown adipose tissue is generally positive against obesity and diabetes, there are no studies on the question of how cold induces fat dissolution in the development of atherosclerosis. If our preclinical findings can be successfully translated into clinical settings, millions of patients who find themselves at risk of cardiovascular disease could benefit from our work. Our project therefore has significance for the benefit of millions of patients.