Viruses cause a wide range of human diseases of varying severity. In this project, we are mapping the molecules and mechanisms that regulate how viruses (winter vomiting viruses and so-called adeno- and picornaviruses) bind to and infect human cells. This determines, among other things, the cell types, tissues and organs that viruses ultimately infect (viral 'tropism'). We want to use new knowledge about these molecules and mechanisms to develop new drugs that prevent viruses from binding to and thus infecting cells. Our research results can also be used to improve so-called gene therapy, which means 'treatment with genes'. Harmless, 'disarmed' adenoviruses are excellent carriers of foreign genes and effectively transport different genes into our cells. We and many others believe that in the future, gene therapy will be able to treat and/or prevent cancer, infections, hereditary diseases and metabolic disorders. This type of treatment is sensitive and needs to be fine-tuned in several ways. One such way is to ensure that the genes are delivered to the right cells. In other words, disarmed viruses need to be steered away from their usual target cells, and instead directed towards the very cells that need treatment. If we can learn more about the molecules and mechanisms that 'real' viruses use to bind to and attack human cells, then disarmed, gene-carrying viruses can be more easily directed to the right type of cells.