Infection and inflammation underlie many diseases. We can suffer from conditions such as chronic eczema of the skin, or chronic wounds, diseases in which we often see an over-activation of our immune system, leading to a harmful and uncontrolled inflammation. Burn wound infections or post-operative wounds (which in the worst case can lead to sepsis) are other major problems in healthcare, where we currently lack effective prevention strategies and are forced to use a lot of antibiotics. Infection treatments today only attack the microbe, and not the activation of different inflammation cascades in the body. There is therefore an urgent need to develop alternative strategies to counteract infections and the subsequent damaging inflammatory process in wounds and various skin diseases. We have recently discovered several innate protective systems in the body that act in our skin and during wound healing, based on various antibacterial and immunosuppressive peptides. Based on these discoveries, we are trying to develop therapies based on modulating the body's own innate immunity. These "natural" and interfering strategies are more effective and sustainable with respect to the development of resistance, and we therefore hope that the research will expand our treatment options, complementing existing treatments in both local infections (wound infections, postoperative, eczema), as well as deep infections and sepsis.